Infiltrating metastatic cardiac tumor

Adoptive transfer of tumor infiltrating lymphocytes for metastatic cervical cancer

Adoptive T-cell therapies for cancer can induce tumor responses in patients with metastatic melanoma, synovial sarcoma, and B-cell malignancies. However, no cellular therapy has demonstrated activity in a common epithelial tumor. Adoptive transfer of tumor infiltrating lymphocytes (TIL) has high response rates and can induce complete and durable tumor regression in metastatic melanoma. We sough...

Metastatic cardiac tumor demonstrated by 201thallium scan.

A patient with bronchogenic carcinoma had an electrocardiogram that was initially thought to be consistent with myocardial infarction and possible left ventricular aneurysm. A heart scan with radioactive 201thallium showed an area of sharply diminished uptake ("cold spot"); however, subsequent thoracotomy showed that this was caused by local pericardial and myocardial infiltration by tumor. Thi...

Tumor-infiltrating effector cells of α-galactosylceramide-induced antitumor immunity in metastatic liver tumor

BACKGROUND: alpha-Galactosylceramide (alpha-GalCer) can be presented by CD1d molecules of antigen-presenting cells, and is known to induce a potent NKT cell-dependent cytotoxic response against tumor cells. However, the main effector cells in alpha-GalCer-induced antitumor immunity are still controversial. METHODS: In order to elucidate the cell phenotype that plays the most important role in a...

Tumor-infiltrating B cells

B cells infiltrating into solid tumors are poorly investigated despite their described positive prognostic value. Whether this antitumor potential comes from either the antigen presentation or the antibody production capacity of B cells, or both, is unknown. Our recently published method on tumor-infiltrating B lymphocyte cloning may prove helpful in unraveling the actual relevance of these cel...

Tumor-Infiltrating Macrophages Induce